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KMID : 0978920120130020194
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Korean Journal of Clinical Geriatrics
2012 Volume.13 No. 2 p.194 ~ p.202
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Association between Hypertriglyceridemic Waist Phenotype and Pulse Wave Velocity in Korean Men
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Lee Ja-Hyung
Chun Hye-Jin
Shim Kyung-Won
Lee Hong-Soo
Lee Sang-Wha
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Abstract
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Background: Atherosclerotic cardiovascular disease is a leading cause of death. There have been many studies about metabolic syndrome and Framingham risk scores associated with cardiovascular disease risk. Recently, some studies about association of hypertriglyceridemic waist (increased waist circumference as well as high fasting triglyceride level) with the cardiovascular disease risk are announced. The pulse wave velocity is used as an indicator of atherosclerotic cardiovascular disease. The aim of this study was to investigate the relationship between hypertriglyceridemic waist and pulse wave velocity in Korean men.
Methods: Study participants were 1,354 subjects above the age of 20 who attended for routine medical examination at health center of a general hospital in Seoul. Those patients with cardiovascular disease or other systemic disease were excluded. Hypertriglyceridemic waist was defined as waist circumference ≥ 90 cm and triglyceride ≥ 177 mg/dL. Subjects were stratified on quartile of pulse wave velocity. Relative risk of hypertriglyceridemic waist and metabolic syndrome for the highest quartile reflecting atherosclerotic cardiovascular disease risk was assessed by logistic regression analysis.
Results: Those with hypertriglyceridemic waist or metabolic syndrome had increased odds ratio for the highest pulse wave velocity quartile. Hypertriglyceridemic waist was associated with 1.5-fold (95% confidence interval, 1.02 to 2.26) increased risk and metabolic syndrome was associated with 1.35-fold (95% confidence interval, 1.04 to 1.75) increased risk. Hypertriglyceridemic waist had higher relative risk for the highest than metabolic syndrome.
Conclusion: Hypertriglyceridemic waist is associated with increased aortic pulse wave velocity and may be the simple predictor of atherosclerotic cardiovascular disease in practice.
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KEYWORD
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Hypertriglyceridemic waist, Metabolic syndrome, Aortic pulse w ave velocity, Cardiovascular disease
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